369 research outputs found

    Challenges and Opportunities for Information Systems Research During and After Coronavirus

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    The COVID-19 pandemic has affected world-wide business and management immensely. Furthermore, challenges and opportunities for information systems research during and after coronavirus have emerged. To better understand the impacts of COVID-19 pandemic in the field of information systems (IS), and also as a part of the 2020 AIS SIG-ISAP Workshop on Information Systems in Asia Pacific (ISAP) being held prior ICIS-2020, we organized a panel to address this important issue with three distinguished information systems researchers. The panelists identified and discussed the challenges and opportunities for information systems research during and after Coronavirus. In addition, constructive suggestions for aspiring young scholars who aim to publish their works in top-tier IS journals have been proposed, which may benefit the IS community in large

    Disclosure Analysis for Two-Way Contingency Tables

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    Ministry of Education, Singapore under its Academic Research Funding Tier 1; SMU Research Offic

    Role Mining in the Presence of Noise

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    Abstract. The problem of role mining, a bottom-up process of discovering roles from the user-permission assignments (UPA), has drawn increasing attention in recent years. The role mining problem (RMP) and several of its variants have been proposed in the literature. While the basic RMP discovers roles that exactly represent the UPA, the inexact variants, such as the δ-approx RMP and MinNoise-RMP, allow for some inexactness in the sense that the discovered roles do not have to exactly cover the entire UPA. However, since data in real life is never completely clean, the role mining process is only effective if it is robust to noise. This paper takes the first step towards addressing this issue. Our goal in this paper is to examine if the effect of noise in the UPA could be ameliorated due to the inexactness in the role mining process, thus having little negative impact on the discovered roles. Specifically, we define a formal model of noise and experimentally evaluate the previously proposed algorithm for δ-approx RMP against its robustness to noise. Essentially, this would allow one to come up with strategies to minimize the effect of noise while discovering roles. Our experiments on real data indicate that the role mining process can preferentially cover a lot of the real assignments and leave potentially noisy assignments for further examination. We explore the ramifications of noisy data and discuss next steps towards coming up with more effective algorithms for handling such data

    A Microalbuminuria Threshold to Predict the Risk for the Development of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients

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    OBJECTIVE: To test the hypothesis that a microalbuminuria (MA) threshold can help predict the risk for the development of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM)_ patients. DESIGN: We conducted a cross-sectional study of 4739 subjects with T2DM and a prospective study of 297 subjects with T2DM in China respectively. METHODS: Clinical and laboratory data were collected and biologic risk factors associated with any DR were analysed. RESULTS: In the cross-sectional study, we found that MA was an independent risk factor for DR development; further, when the patients were divided into MA deciles, odds ratio (ORs) of DR for the patients in the sixth MA decile (10.7 mg/24 h) was 1.579-fold (1.161-2.147) compared to that for patients in the first MA decile. Furthermore, the OR of DR increased with a gradual increase in MA levels. Similarly, in the prospective study, during a mean follow-up of 4.5 years, we found that 51 patients (29.0%) of the 176 subjects with high MA level (10.7-30 mg/24 h) developed DR, while 17 patients (14.1%) of the 121 subjects with lower MA (<10.7 mg/24 h) developed DR, and the relative risk ratio of the development of DR is 2.13(95% CI, 1.58-3.62, P<0.001). CONCLUSION: These data suggest that an MA threshold can predict the risk for the development of DR in type 2 diabetes mellitus, although it is still within the traditionally established normal range

    Integrative analysis of chloroplast genome, chemicals, and illustrations in Bencao literature provides insights into the medicinal value of Peucedanum huangshanense

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    The genus Peucedanum L. (Apiaceae) is a large group comprising more than 120 species distributed worldwide. Many plants of the genus Peucedanum have been studied and used in traditional Chinese medicine. In 2020, a new species, Peucedanum huangshanense Lu Q. Huang, H. S. Peng &amp; S. S. Chu, was found in the Huangshan Mountains of Anhui Province, China. However, little is known about its medicinal properties. Thus, the objective of this study is to explore the potential medicinal value of P. huangshanense and its relationship with other Peucedanum species. Through textual research on illustrations of Qianhu in Bencao literature, it can be inferred that at least five species of genus Peucedanum have been used in Chinese medicine. Therefore, we chose these five species of Peucedanum and P. huangshanense together for subsequent research. We conducted morphological, chloroplast genome, and chemical analyses of six Peucedanum species, including the newly discovered P. huangshanense. The chloroplast genomes of Peucedanum showed a typical tetrad structure, and the gene structure and content were similar and conservative. There were significant differences in genome size and the expansion of the inverted repeat boundary. Through nucleotide polymorphism analysis, we screened 14 hotspot mutation regions that have the potential to be used as specific molecular markers for the taxonomy of Peucedanum. Our results showed an inversion of the trnD-trnY-trnE gene in the P. huangshanense chloroplast genome, which can be developed as a specific molecular marker for species identification. Phylogenetic analysis showed that the phylogenetic trees had high support and resolution, which strongly supports the view that Peucedanum is not a monophyletic group. P. huangshanense had the closest genetic relationship to P. ampliatum K. T. Fu, followed by P. harry-smithii Fedde ex Wolff. Furthermore, the main coumarins of P. huangshanense were most similar to those of P. japonicum Thunb. and P. harry-smithii. In summary, our research lays a foundation for the systematic classification of Peucedanum and sheds light on the medicinal value of P. huangshanense
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